Research Activities


Our group has a unique set of expertize ranging from DNP, quadrupolar & biomolecular NMR, computational chemistry as well as advanced instrumentation development (especially in cryogenics). Notably our expertise ranges from theoretical spin dynamics in the solid-state to the design of advanced solid-state NMR experiments for improving sensitivity and resolution. 
This theoretical and experimental knowhow allows for a deep understanding of issues involved in the structural determination of macromolecules (such as amyloid fibrils and self-assembled nanostructures) and advanced materials. The methodological and instrumental developments, currently on-going in our lab (pulse sequences, data treatment, sample preparation, etc.), are tailored to the complex molecular systems under study, of interest for energy, health, and the development of new (nano)-materials.

 


          Instrumentation…            Theory...              Application...

                         
       
    






 







  • New methods for recoupling in solid-state NMR

Dipolar Recoupling in Magic Angle Spinning Solid-State Nuclear Magnetic Resonance


  • New approaches for DNP-enhanced solid-state NMR


Optimization of an absolute sensitivity in a glassy matrix during DNP-enhanced multidimensional solid-state NMR experiments





Matrix-free dynamic nuclear polarization enables solid-state NMR 13C–13C correlation spectroscopy of proteins at natural isotopic abundance








  • DNP-enhanced NMR of quadrupolar nuclei

Enhanced Solid-State NMR Correlation Spectroscopy of Quadrupolar Nuclei Using Dynamic Nuclear Polarization













  • Advanced instrumentation for DNP-enhanced solid-state NMR

           




Pushing NMR sensitivity limits using dynamic nuclear polarization with closed-loop cryogenic helium sample spinning





           














Towards Structure Determination of Self-Assembled Peptides Using Dynamic Nuclear Polarization Enhanced Solid-State NMR Spectroscopy



                                                                          

          
           










  • On-cell NMR using DNP